iiiGatlik
High Throughput Screening Systems
High Throughput Screening Systems
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Electroactive Pharmaceutical Screening (EPS) System The Gatlik EPS System is novel, automated high-throughput screening equipment, suitable for assessing the oxidative, reductive and metabolic stability of new drug candidates at the early stage of lead optimization. The determination is based on intrinsic electrochemical parameters of tested compounds and does not require any biological material. The EPS System allows to electrochemically produce the first pass metabolites of drugs in reactions like dehydrogenation, N-, S-, C- oxidation and N-, O- dealkylation with the activation reflecting Cytochrome P450 redox processes. The innovative aspect of this analytical and production device is the application of electronic sensors for stability investigation of new chemical entities. Therefore, a conventional 96-well plate has been replaced with a 96-sensor plate, where electronic sensors and transducers are located in each well of the plate. The EPS device does not require any enzymes or organic material and is not restricted to certain compound types. The system principle was extensively evaluated by various assays and types of compounds. This innovative technology shows promising results for a variety of applications beyond metabolic screens, e.g. in formulation development, antioxidant profiling or hepatotoxicity prediction. In detail, the Gatlik EPS System consists of:
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